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Ling Qi

Assistant Professor

Graduate Fields

Research Focus

Qi lab is interested in the transcription regulation of unfolded protein response and inflammation response in obesity and diabetes. He will use biochemical, genetic, immunological and high throughput approaches to study these fundamental questions. For more information, please visit our lab website.

Educational Background

  • Postdoctoral training, Johns Hopkins University (2001-2004) and Salk Institute (2004-2007)
  • Ph.D.,  University of Maryland  (1997-2001)
  • B.S.,  Fudan University, Shanghai, China (1993-1997)

Research Grants

  • GENETIC CONTROL OF CROSSTALK BETWEEN MACROPHAGES AND ADIPOCYTES
  • MANIPULATION OF UNFOLDED PROTEIN RESPONSE IN NEURODEGENERATION

Selected Publications

PubMed Listings

Qi, L.1, Heredia, J.1, Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., MacLeod, I.X., Liew, C.W., Kulkarni, R., Bain, J., Nelson, M., Evans, R.M., Yates, J., and Montminy, M. 2006.  TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 312: 1763-6  (1, contribute equally)

Koo, S.H.1, Flechner, L.1, Qi, L. Zhang, X., Screaton, R.A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., and Montminy, M. 2005.  The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 437: 1109-11 (1, contribute equally)

Qi, L., Strong, M.A., Karim, B.O., Huso, D.L., and Greider, C.W. 2004. Telomere fusion to chromosome breaks reduces oncogenic translocations and tumor formation. Nature Cell Biology. 7: 706-11. 

Dolan, B.P., Phelan, T.P., Ilkovitch, D., Qi, L., Wade, W.F., Laufer, T.M., and Ostrand-Rosenberg, S. 2004. Invariant chain and the MHC class II cytoplasmic domains regulate localization of MHC class II molecules to lipid rafts in tumor cell-based vaccines. J. Immunol. 172: 907-14.

Qi, L., Strong, M.A., Karim, B.O., Armanois, M., Huso, D.L., and Greider, C.W. 2003. Short telomeres and ataxia-telangiectasia mutated (ATM) deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis. Cancer Res. 63: 8188-96.

 Ostrand-Rosenberg, S., Clements, V., Dissanayake, S., Pulaski, B., and Qi, L. 2002.  Immunological targets for the gene therapy of cancer.  In Gene therapy of cancer, II. E. Latteime, and S. Gerson, eds. Academic Press, San Diego.  Part II, 128-138.