Manfred Lindau
Professor of Applied and Engineering Physics and Coordinator of the Engineering Physics Cooperative Program
Primary Research Areas
- biomedical instrumentation and diagnostics
- biophysics
- nanoscience and nanobiotechnology
Graduate Fields
Research Focus
- Understanding the fusion of secretory vesicles with the plasma membrane, or exocytosis
- Use techniques of patch clamp, electro-chemistry fluorescence microscopy, image processing, optical traps and related biochemical processes
- Apply research to neurobiology, in which regulated exocytosis is responsible for the release of neurotransmitters and the subsequent flow of events from this release
- Achieve better understanding of the mechanisms of membrane fusion, provide insight into ways these processes can be manipulated and establish a foundation to design improved delivery systems for drugs or DNA for gene therapy
- Characterization of single exocytotic events in cell: attached patches using capacitance measurements and amperometry
- Spatio-temporal dynamics of exocytosis using nanofabricated electrochemical detector arrays
- Reconstitution of exocytosis in excised membrane patches
- Direct visualization of the degranulation process in white blood cells using modern microscopic imaging methods
- Characterization of docking and fusion between secretory granules and between specific components of the exocytotic machinery using optical tweezers
Educational Background
- B.S., University of Hamburg, Germany: physics, 1977
- Ph.D., Technical University of Berlin: chemistry, 1983
- Habil., Free University of Berlin: experimental physics, 1991
Other Pages
Departments
Research Grants
- MECHANISM FOR FUSION AND TRANSMITTER RELEASE IN NEUROSECRETION
- MECHANISMS OF FUSION TRANSMITTER RELEASE IN NEUROSECRETION
- MICROCHIP DEVICES TO ASSAY QUANTAL EXOCYTOSIS
Selected Publications
PubMed Listings77. K.Berberian, K. Kisler, Q.Fang, and M.Lindau (2009)
Improved surface patterned platinum microelectrodes for the study of exocytotic events, Anal. Chem. in press.
76. R.Dong, M.Lindau and C.K.Ober (2009)
Dissociation behavior of weak polyelectrolyte brushes on a planar surface. Langmuir, 25:4774-4779.
75. K.Berberian, A.Torres, Q.Fang, K.Kisler and M.Lindau (2009)
F-actin and myosin II accelerate catecholamine release from chromaffin granules, J. Neurosci. 29: 863-870.
74. Q.Fang, L.W.Gong, K.Berberian ,I.Hafez, J.Sørensen and M.Lindau (2008)
The role of the C-terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics, Proc. Natl. Acad. Sci., 105: 15388-15392.
73. V.Valero, T.Nevian, D.Ho and M.Lindau (2008)
Tethering forces of secretory granules measured with optical tweezers, Biophys. J. 95: 4972-4978.
72. M. Lindau (2008)
Fusion gains independence, J. Gen. Physiol. 132: 9-11.
71. R.Dong, S.Krishnan, B.A.Baird, M.Lindau, and C.K.Ober (2007)
Patterned Biofunctional Poly(Acrylic Acid) Brushes on Silicon Surfaces, Biomacromolecules, 8: 3082-3092.
70. L.W.Gong, G. Alvarez de Toledo and M.Lindau (2007)
Exocytotic catecholamine release is not associated with cation flux through channels in the vesicle membrane but Na+ influx through the fusion pore, Nature Cell Biology, 9: 915-922.
69. S.Ayers, K.Gillis, M. Lindau and B.A.Minch (2007)
Design of a CMOS potentiostat circuit for electrochemical detector arrays, IEEE Transactions on Circuits & Systems I, 54: 736-744.
68. G.Dernick, G.Alvarez de Toledo and M.Lindau (2006)
The Patch Amperometry Technique: Design of a Method to Study Exocytosis of Single Vesicles. In Electrochemical Methods for Neuroscience. A.C. Michael and L.M. Borland, editors. CRC Press, Boca Raton, FL. 315-336.
67. R.Borges and M.Lindau (2006)
Kavli Workshop in Pucon - Advanced Techniques to Study Single Vesicle Exocytosis, N.Y. Acad. Sci. eBriefings, http://www.nyas.org/ebriefreps/splash.asp?intebriefID=532
66. L.L.Muldoon, P.G.Tratnyek, P.M.Jacobs, N.D.Doolittle, G.A.Christoforidis, J.A.Frank, M.Lindau, P.R.Lockman, S.P.Manninger, Y.Qiang, A.M.Spence, S.I.Stupp, M.Zhang and E.A.Neuwelt (2006)
Imaging and nanomedicine for diagnosis and therapy in the central nervous system: Report of the eleventh annual blood-brain barrier disruption consortium meeting, Am. J. Neuroradiol. 27: 715-721
65. I.Hafez, K.Kisler, K.N.Berberian, G.Dernick, V.Valero, M.G.Yong, H.G.Craighead and M.Lindau (2005)
Electrochemical imaging of fusion pore openings by electrochemical detector arrays, Proc. Natl. Acad. Sci. 102: 13879-13884.
64. G.Dernick, L.W.Gong, L.Tabares, G. Alvarez de Toledo and M.Lindau (2005)
Patch Amperometry - high resolution measurements of single vesicle fusion and release, Nature Methods 2: 699-708.
63. L.W.Gong , G.Di Paolo, E.Diaz, G.Cestra, E.Diaz, M.Lindau, P.DeCamilli and D.Toomre (2005)
Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion, Proc. Natl. Acad. Sci. 102: 5204-5209.
62. I.Hafez, A.Stolpe and M.Lindau (2003)
Compound exocytosis and cumulative fusion in eosinophils, J. Biol. Chem. 278: 44921-44928.
61. J.Hartmann, S.Scepek, I.Hafez and M.Lindau (2003)
Differential regulation of exocytotic fusion and granule- granule fusion in eosinophils by Ca2+ and GTP analogs, J. Biol. Chem. 278: 44929-44934.
60. M.Lindau (2003)
Synaptotagmin function illuminated. J.Gen.Physiol. 122: 251-254.
59. L.W.Gong, I.Hafez, G. Alvarez de Toledo and M.Lindau (2003)
Secretory vesicles membrane area is regulated in tandem with quantal size in chromaffin cells, J. Neurosci. 23: 7917-7921
58. M.Lindau and G. Alvarez de Toledo (2003)
The fusion pore, Biochim. Biophys. Acta – Mol. Cell Res. 1641: 167-173.
57. Tabares, L., M. Lindau, and G. Alvarez De Toledo. 2003.
Relationship between fusion pore opening and release during mast cell exocytosis studied with patch amperometry. Biochem Soc Trans. 31:837-41.
56. E.V. Mosharov, L.W. Gong , B. Khanna, D. Sulzer and M. Lindau (2003)
Intracellular patch electrochemistry: Regulation of cytosolic catecholamines in chromaffin cells, J. Neurosci. 23: 5835-5845.
55. G.Dernick, G.Alvarez de Toledo and M.Lindau (2003)
Exocytosis of single chromaffin granules in cell-free inside-out membrane patches, Nature Cell Biol. 5: 358-362.
54. A.F.Dias, G.Dernick, V.Valero, M.G.Yong, C.D.James, H.G.Craighead and M.Lindau (2002)
An electrochemical detector array to study cell biology on the nanoscale, Nanotechnology 13: 285-289.
53. K. Lollike, M.Lindau, J.Calafat and N.Borregaard (2002)
Compound exocytosis of granules in human neutrophils, J.Leukoc.Biol. 71: 973-980.
52. L.Tabares, E.Alés, M.Lindau and G. Alvarez de Toledo (2001)
Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells, J. Biol. Chem. 276: 39974-39979.
51. R.E.Thompson, M.Lindau and W.W.Webb (2001)
Robust whole cell patch-clamp capacitance measurements using square wave simulation, Biophys. J. 81: 937-948.
50. G.Kilic and M.Lindau (2001)
Voltage dependent membrane capacitance in rat pituitary nerve terminals due to gating currents, Biophys. J. 80: 1220-1229.
49. K.Debus and M. Lindau (2000)
Resolution of patch capacitance recordings and of fusion pore conductances in small vesicles, Biophys. J. 78: 2983-2997.
48. A.W.Henkel, H.Meiri, H.Horstmann, M.Lindau & W.Almers (2000)
Rhythmic opening and closing of vesicles during constitutive exo- and endocytosis in chromaffin cells, EMBO J.,19: 84-93.
47. K.Lollike and M.Lindau (1999)
Membrane capacitance techniques to monitor granule exocytosis in neutrophils, J. Immunol. Methods, 232: 111-120.
46. E.Alés, L.Tabares, J.M.Poyato, V.Valero, M.Lindau and G. Alvarez de Toledo (1999)
High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism, Nature Cell Biol., 1: 40-44.
45. D.Lorenz, B.Wiesner,J.Zipper, A.Winkler, E.Krause, M.Beyermann, M.Lindau and M.Bienert (1998)
Mechanism of peptide-induced mast cell degranulation: translocation and patch clamp studies, J. Gen. Physiol. 112: 577-591.
44. M.Lindau (1998)
Fusion proteins and the fusion events, in Secretory Systems and Toxins (Cellular & molecular mechanisms of toxin action), eds. M.Linial, A.Grasso and P.Lazarovici, Harwood Academic Publishers: 131-146.
43. S.Scepek, J.Coorssen and M.Lindau (1998)
Fusion pore expansion in horse eosinophils is modulated by Ca2+ and protein kinase C via distinct mechanisms, EMBO J. 17: 4340-4345.
42. K.Lollike, N.Borregaard and M.Lindau (1998)
Capacitance flickers and “pseudoflickers” of small granules, measured in the cell attached configuration, Biophys. J. 75: 53-59.
41. A.Albillos, G.Dernick, H.Horstmann, W.Almers, G.Alvarez de Toledo and M.Lindau (1997)
The exocytotic event in chromaffin cells revealed by patch amperometry, Nature 389: 509-512.
40. S.Scepek and M.Lindau (1997)
Exocytotic competence and intergranular fusion in cord blood-derived eosinophils during differentiation, Blood 89:510-517.
39. G.Kilic, A.Stolpe and M.Lindau (1996)
A slowly activating voltage-dependent K+ current in rat pituitary nerve terminals, J. Physiol. 497:711-725.
38. K.Debus, J.Hartmann, G.Kilic and M.Lindau (1995)
Influence of conductance changes on patch clamp capacitance measurements using a lock-in amplifier and limitations of the phase tracking technique, Biophys. J. 69:2808-2822.
37. M.Lindau and W.Almers (1995)
Structure and function of fusion pores in exocytosis and ectoplasmic fusion, Curr. Opin. Cell Biol. 7:509-517.
36. K.Lollike, N.Borregaard and M.Lindau (1995)
The exocytotic fusion pore of small granules has a conductance similar to an ion channel, J. Cell Biol. 129:99-104.
35. J.Hartmann and M.Lindau (1995)
A novel Ca2+ dependent step in exocytosis subsequent to vesicle fusion, FEBS Lett. 363:217-220.
34. J.Hartmann, S.Scepek and M.Lindau (1995)
Regulation of granule size in human and horse eosinophils by number of fusion events among unit granules, J. Physiol. 483:201-209.
33. J.Dietrich and M.Lindau (1994)
Chloride channels in mast cells - block by DIDS and role in exocytosis, J. Gen. Physiol. 104: 1099-1111.
32. S.Scepek, R.Moqbel and M.Lindau (1994)
Compound exocytosis and cumulative degranulation by eosinophils and its role in parasite killing, Parasitol. Today 10: 276-278.
31. M.Lindau, H.Rosenboom and J.J.Nordmann (1994)
Exocytosis and endocytosis in single peptidergic nerve terminals, Adv. Second Messenger Phosphoprotein Res. 29: 173-187.
30. H.Rosenboom and M.Lindau (1994)
Exo-endocytosis and closing of the fission pore during endocytosis in single pituitary nerve terminals internally perfused with high calcium concentrations, Proc. Natl. Acad. Sci. 91: 5267-5271.
29. M.Lindau, J.Hartmann and S.Scepek (1994)
Three distinct fusion events during eosinophil degranulation, Annals N. Y. Acad. Sci. 710: 232-247.
28. O.Cromwell, B.D.Gomperts and M.Lindau (1993)
G-Protein Regulation of Eosinophil Exocytosis, in: Eosinophils in Allergy and Inflammation, eds. G.J.Gleich and A.B.Kay, M.Dekker, New York: 55-67.
27. S.Scepek and M.Lindau (1993)
Focal exocytosis by eosinophils - compound exocytosis and cumulative fusion, EMBO J. 12:1811-1817.
26. O.Nüße, and M.Lindau (1993)
The calcium signal in human neutrophils and its relation to exocytosis, Cell Calcium 14:255-269.
25. M.Lindau, O.Nüße, J.Bennett and O.Cromwell (1993)
The membrane fusion events in degranulating guinea-pig eosinophils, J. Cell Sci. 104:203-209.
24. J.Nordmann, M.Lindau and E.L.Stuenkel (1992)
Sodium, calcium and exocytosis: Confessions of calcified scientists, J. Physiol. (Paris) 86:15-21.
23. M.Lindau, E.Stuenkel and J.Nordmann (1992)
Depolarization, intracellular calcium and exocytosis in single vertebrate nerve endings, Biophys. J. 61:19-30.
22. M.Lindau (1991)
Eine biophysikalische Methode revolutioniert die Zellbiologie, Physikalische Blätter 47:1002-1003.
21. M.Lindau and B.D.Gomperts (1991)
Techniques and concepts in exocytosis: focus on mast cells, Biochim. Biophys. Acta, Reviews in Biomembranes 1071:429-471.
20. M.Lindau (1991)
Time-resolved capacitance measurements: Monitoring exocytosis in single cells, Quart. Rev. Biophys. 24:75-101.
19. O.Nüße, M.Lindau, O.Cromwell, A.B.Kay and B.D.Gomperts (1990)
Intracellular application of GTP-γ-S induces exocytotic granule fusion in guinea-pig eosinophils, J. Exp. Med. 171:775-786.
18. P.E.R.Tatham and M.Lindau (1990)
ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells, J. Gen. Physiol. 95:459-476.
17. O. Nüße and M.Lindau (1990)
GTP-γ-S-induced calcium transients and exocytosis in human neutrophils, Biosci. Rep. 10:93-103.
16. H.Otto, T.Marti, M.Holz, T.Mogi, M.Lindau, H.G.Khorana and M.P.Heyn (1989)
Asp96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin. Proc. Natl. Acad. Sci. 86:9228-9232.
15. M.P.Heyn, D.Braun, N.A.Dencher, A.Fahr, M.Lindau, F.Seiff, I.Wallat and J.Westerhausen (1988)
Chromophore location and charge displacement in bacteriorhodopsin, Ber. Bunsenges. Phys. Chem. 92:1045-1050.
14. O.Nüße and M.Lindau (1988)
The dynamics of exocytosis in human neutrophils, J. Cell Biol. 107:2117-2123.
13. M.Holz, M.Lindau and M.P.Heyn (1988)
Distributed kinetics of the light-induced charge movements in bacteriorhodopsin, Biophys. J. 53:623-633.
12. D.Braun, N.A.Dencher, A.Fahr, M.Lindau and M.P.Heyn (1988)
Nonlinear voltage dependence of the proton pump current of bacteriorhodopsin, Biophys. J. 53:617-621.
11. M.Lindau and E.Neher (1988)
Patch-clamp techniques for time-resolved capacitance measurements in single cells, Pflügers Arch. 411:137-146.
10. E.Neher, J.M.Fernandez and M.Lindau (1987)
The calcium dependence of vesicle exocytosis, in: Molecular Neurobiology in Neurology and Psychiatry, ed. E.R.Kandel, Raven Press, New York: 103-110.
9. M.Lindau and O.Nüße (1987)
Pertussis toxin does not affect the time course of exocytosis in mast cells stimulated by intracellular application of GTP-γ-S, FEBS Lett. 222:317-321.
8. J.M.Fernandez, M.Lindau and F.Eckstein (1987)
Intracellular stimulation of mast cells with guanine nucleotides mimick antigenic stimulation, FEBS Lett. 216:89-93.
7. M.Lindau and J.M.Fernandez (1986)
A patch-clamp study of histamine-secreting cells, J. Gen. Physiol. 88:349-368.
6. M.Lindau and J.M.Fernandez (1986)
IgE-mediated degranulation of mast cells does not require opening of ion channels, Nature 319:150-153.
5. M.Lindau and H.Rüppel (1985)
On the nature of the fast light-induced charge displacement in vertebrate photoreceptors, Photobiochem. Photobiophys. 9:43-56.
4. M.Lindau (1984)
Lichtinduzierte Ladungsbewegungen des Rhodopsins, Dissertation Technische Universität Berlin.
3. M.Lindau and H.Rüppel (1983)
Evidence for conformational substates of rhodopsin from kinetics of light-induced charge displacement, Photobiochem. Photobiophys. 5:219-228.
2. P.Hochstrate, M.Lindau and H.Rüppel (1982)
On the origin and signal-shaping mechanism of the fast photo-signal in the vertebrate retina, Biophys. J. 38:53-61.
1. M.Lindau, P.Hochstrate and H.Rüppel (1980)
Two component fast photo-signals derived from rod outer segment membranes attached to porous cellulose filters, FEBS Lett. 112:17-20.
Improved surface patterned platinum microelectrodes for the study of exocytotic events, Anal. Chem. in press.
76. R.Dong, M.Lindau and C.K.Ober (2009)
Dissociation behavior of weak polyelectrolyte brushes on a planar surface. Langmuir, 25:4774-4779.
75. K.Berberian, A.Torres, Q.Fang, K.Kisler and M.Lindau (2009)
F-actin and myosin II accelerate catecholamine release from chromaffin granules, J. Neurosci. 29: 863-870.
74. Q.Fang, L.W.Gong, K.Berberian ,I.Hafez, J.Sørensen and M.Lindau (2008)
The role of the C-terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics, Proc. Natl. Acad. Sci., 105: 15388-15392.
73. V.Valero, T.Nevian, D.Ho and M.Lindau (2008)
Tethering forces of secretory granules measured with optical tweezers, Biophys. J. 95: 4972-4978.
72. M. Lindau (2008)
Fusion gains independence, J. Gen. Physiol. 132: 9-11.
71. R.Dong, S.Krishnan, B.A.Baird, M.Lindau, and C.K.Ober (2007)
Patterned Biofunctional Poly(Acrylic Acid) Brushes on Silicon Surfaces, Biomacromolecules, 8: 3082-3092.
70. L.W.Gong, G. Alvarez de Toledo and M.Lindau (2007)
Exocytotic catecholamine release is not associated with cation flux through channels in the vesicle membrane but Na+ influx through the fusion pore, Nature Cell Biology, 9: 915-922.
69. S.Ayers, K.Gillis, M. Lindau and B.A.Minch (2007)
Design of a CMOS potentiostat circuit for electrochemical detector arrays, IEEE Transactions on Circuits & Systems I, 54: 736-744.
68. G.Dernick, G.Alvarez de Toledo and M.Lindau (2006)
The Patch Amperometry Technique: Design of a Method to Study Exocytosis of Single Vesicles. In Electrochemical Methods for Neuroscience. A.C. Michael and L.M. Borland, editors. CRC Press, Boca Raton, FL. 315-336.
67. R.Borges and M.Lindau (2006)
Kavli Workshop in Pucon - Advanced Techniques to Study Single Vesicle Exocytosis, N.Y. Acad. Sci. eBriefings, http://www.nyas.org/ebriefreps/splash.asp?intebriefID=532
66. L.L.Muldoon, P.G.Tratnyek, P.M.Jacobs, N.D.Doolittle, G.A.Christoforidis, J.A.Frank, M.Lindau, P.R.Lockman, S.P.Manninger, Y.Qiang, A.M.Spence, S.I.Stupp, M.Zhang and E.A.Neuwelt (2006)
Imaging and nanomedicine for diagnosis and therapy in the central nervous system: Report of the eleventh annual blood-brain barrier disruption consortium meeting, Am. J. Neuroradiol. 27: 715-721
65. I.Hafez, K.Kisler, K.N.Berberian, G.Dernick, V.Valero, M.G.Yong, H.G.Craighead and M.Lindau (2005)
Electrochemical imaging of fusion pore openings by electrochemical detector arrays, Proc. Natl. Acad. Sci. 102: 13879-13884.
64. G.Dernick, L.W.Gong, L.Tabares, G. Alvarez de Toledo and M.Lindau (2005)
Patch Amperometry - high resolution measurements of single vesicle fusion and release, Nature Methods 2: 699-708.
63. L.W.Gong , G.Di Paolo, E.Diaz, G.Cestra, E.Diaz, M.Lindau, P.DeCamilli and D.Toomre (2005)
Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion, Proc. Natl. Acad. Sci. 102: 5204-5209.
62. I.Hafez, A.Stolpe and M.Lindau (2003)
Compound exocytosis and cumulative fusion in eosinophils, J. Biol. Chem. 278: 44921-44928.
61. J.Hartmann, S.Scepek, I.Hafez and M.Lindau (2003)
Differential regulation of exocytotic fusion and granule- granule fusion in eosinophils by Ca2+ and GTP analogs, J. Biol. Chem. 278: 44929-44934.
60. M.Lindau (2003)
Synaptotagmin function illuminated. J.Gen.Physiol. 122: 251-254.
59. L.W.Gong, I.Hafez, G. Alvarez de Toledo and M.Lindau (2003)
Secretory vesicles membrane area is regulated in tandem with quantal size in chromaffin cells, J. Neurosci. 23: 7917-7921
58. M.Lindau and G. Alvarez de Toledo (2003)
The fusion pore, Biochim. Biophys. Acta – Mol. Cell Res. 1641: 167-173.
57. Tabares, L., M. Lindau, and G. Alvarez De Toledo. 2003.
Relationship between fusion pore opening and release during mast cell exocytosis studied with patch amperometry. Biochem Soc Trans. 31:837-41.
56. E.V. Mosharov, L.W. Gong , B. Khanna, D. Sulzer and M. Lindau (2003)
Intracellular patch electrochemistry: Regulation of cytosolic catecholamines in chromaffin cells, J. Neurosci. 23: 5835-5845.
55. G.Dernick, G.Alvarez de Toledo and M.Lindau (2003)
Exocytosis of single chromaffin granules in cell-free inside-out membrane patches, Nature Cell Biol. 5: 358-362.
54. A.F.Dias, G.Dernick, V.Valero, M.G.Yong, C.D.James, H.G.Craighead and M.Lindau (2002)
An electrochemical detector array to study cell biology on the nanoscale, Nanotechnology 13: 285-289.
53. K. Lollike, M.Lindau, J.Calafat and N.Borregaard (2002)
Compound exocytosis of granules in human neutrophils, J.Leukoc.Biol. 71: 973-980.
52. L.Tabares, E.Alés, M.Lindau and G. Alvarez de Toledo (2001)
Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells, J. Biol. Chem. 276: 39974-39979.
51. R.E.Thompson, M.Lindau and W.W.Webb (2001)
Robust whole cell patch-clamp capacitance measurements using square wave simulation, Biophys. J. 81: 937-948.
50. G.Kilic and M.Lindau (2001)
Voltage dependent membrane capacitance in rat pituitary nerve terminals due to gating currents, Biophys. J. 80: 1220-1229.
49. K.Debus and M. Lindau (2000)
Resolution of patch capacitance recordings and of fusion pore conductances in small vesicles, Biophys. J. 78: 2983-2997.
48. A.W.Henkel, H.Meiri, H.Horstmann, M.Lindau & W.Almers (2000)
Rhythmic opening and closing of vesicles during constitutive exo- and endocytosis in chromaffin cells, EMBO J.,19: 84-93.
47. K.Lollike and M.Lindau (1999)
Membrane capacitance techniques to monitor granule exocytosis in neutrophils, J. Immunol. Methods, 232: 111-120.
46. E.Alés, L.Tabares, J.M.Poyato, V.Valero, M.Lindau and G. Alvarez de Toledo (1999)
High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism, Nature Cell Biol., 1: 40-44.
45. D.Lorenz, B.Wiesner,J.Zipper, A.Winkler, E.Krause, M.Beyermann, M.Lindau and M.Bienert (1998)
Mechanism of peptide-induced mast cell degranulation: translocation and patch clamp studies, J. Gen. Physiol. 112: 577-591.
44. M.Lindau (1998)
Fusion proteins and the fusion events, in Secretory Systems and Toxins (Cellular & molecular mechanisms of toxin action), eds. M.Linial, A.Grasso and P.Lazarovici, Harwood Academic Publishers: 131-146.
43. S.Scepek, J.Coorssen and M.Lindau (1998)
Fusion pore expansion in horse eosinophils is modulated by Ca2+ and protein kinase C via distinct mechanisms, EMBO J. 17: 4340-4345.
42. K.Lollike, N.Borregaard and M.Lindau (1998)
Capacitance flickers and “pseudoflickers” of small granules, measured in the cell attached configuration, Biophys. J. 75: 53-59.
41. A.Albillos, G.Dernick, H.Horstmann, W.Almers, G.Alvarez de Toledo and M.Lindau (1997)
The exocytotic event in chromaffin cells revealed by patch amperometry, Nature 389: 509-512.
40. S.Scepek and M.Lindau (1997)
Exocytotic competence and intergranular fusion in cord blood-derived eosinophils during differentiation, Blood 89:510-517.
39. G.Kilic, A.Stolpe and M.Lindau (1996)
A slowly activating voltage-dependent K+ current in rat pituitary nerve terminals, J. Physiol. 497:711-725.
38. K.Debus, J.Hartmann, G.Kilic and M.Lindau (1995)
Influence of conductance changes on patch clamp capacitance measurements using a lock-in amplifier and limitations of the phase tracking technique, Biophys. J. 69:2808-2822.
37. M.Lindau and W.Almers (1995)
Structure and function of fusion pores in exocytosis and ectoplasmic fusion, Curr. Opin. Cell Biol. 7:509-517.
36. K.Lollike, N.Borregaard and M.Lindau (1995)
The exocytotic fusion pore of small granules has a conductance similar to an ion channel, J. Cell Biol. 129:99-104.
35. J.Hartmann and M.Lindau (1995)
A novel Ca2+ dependent step in exocytosis subsequent to vesicle fusion, FEBS Lett. 363:217-220.
34. J.Hartmann, S.Scepek and M.Lindau (1995)
Regulation of granule size in human and horse eosinophils by number of fusion events among unit granules, J. Physiol. 483:201-209.
33. J.Dietrich and M.Lindau (1994)
Chloride channels in mast cells - block by DIDS and role in exocytosis, J. Gen. Physiol. 104: 1099-1111.
32. S.Scepek, R.Moqbel and M.Lindau (1994)
Compound exocytosis and cumulative degranulation by eosinophils and its role in parasite killing, Parasitol. Today 10: 276-278.
31. M.Lindau, H.Rosenboom and J.J.Nordmann (1994)
Exocytosis and endocytosis in single peptidergic nerve terminals, Adv. Second Messenger Phosphoprotein Res. 29: 173-187.
30. H.Rosenboom and M.Lindau (1994)
Exo-endocytosis and closing of the fission pore during endocytosis in single pituitary nerve terminals internally perfused with high calcium concentrations, Proc. Natl. Acad. Sci. 91: 5267-5271.
29. M.Lindau, J.Hartmann and S.Scepek (1994)
Three distinct fusion events during eosinophil degranulation, Annals N. Y. Acad. Sci. 710: 232-247.
28. O.Cromwell, B.D.Gomperts and M.Lindau (1993)
G-Protein Regulation of Eosinophil Exocytosis, in: Eosinophils in Allergy and Inflammation, eds. G.J.Gleich and A.B.Kay, M.Dekker, New York: 55-67.
27. S.Scepek and M.Lindau (1993)
Focal exocytosis by eosinophils - compound exocytosis and cumulative fusion, EMBO J. 12:1811-1817.
26. O.Nüße, and M.Lindau (1993)
The calcium signal in human neutrophils and its relation to exocytosis, Cell Calcium 14:255-269.
25. M.Lindau, O.Nüße, J.Bennett and O.Cromwell (1993)
The membrane fusion events in degranulating guinea-pig eosinophils, J. Cell Sci. 104:203-209.
24. J.Nordmann, M.Lindau and E.L.Stuenkel (1992)
Sodium, calcium and exocytosis: Confessions of calcified scientists, J. Physiol. (Paris) 86:15-21.
23. M.Lindau, E.Stuenkel and J.Nordmann (1992)
Depolarization, intracellular calcium and exocytosis in single vertebrate nerve endings, Biophys. J. 61:19-30.
22. M.Lindau (1991)
Eine biophysikalische Methode revolutioniert die Zellbiologie, Physikalische Blätter 47:1002-1003.
21. M.Lindau and B.D.Gomperts (1991)
Techniques and concepts in exocytosis: focus on mast cells, Biochim. Biophys. Acta, Reviews in Biomembranes 1071:429-471.
20. M.Lindau (1991)
Time-resolved capacitance measurements: Monitoring exocytosis in single cells, Quart. Rev. Biophys. 24:75-101.
19. O.Nüße, M.Lindau, O.Cromwell, A.B.Kay and B.D.Gomperts (1990)
Intracellular application of GTP-γ-S induces exocytotic granule fusion in guinea-pig eosinophils, J. Exp. Med. 171:775-786.
18. P.E.R.Tatham and M.Lindau (1990)
ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells, J. Gen. Physiol. 95:459-476.
17. O. Nüße and M.Lindau (1990)
GTP-γ-S-induced calcium transients and exocytosis in human neutrophils, Biosci. Rep. 10:93-103.
16. H.Otto, T.Marti, M.Holz, T.Mogi, M.Lindau, H.G.Khorana and M.P.Heyn (1989)
Asp96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin. Proc. Natl. Acad. Sci. 86:9228-9232.
15. M.P.Heyn, D.Braun, N.A.Dencher, A.Fahr, M.Lindau, F.Seiff, I.Wallat and J.Westerhausen (1988)
Chromophore location and charge displacement in bacteriorhodopsin, Ber. Bunsenges. Phys. Chem. 92:1045-1050.
14. O.Nüße and M.Lindau (1988)
The dynamics of exocytosis in human neutrophils, J. Cell Biol. 107:2117-2123.
13. M.Holz, M.Lindau and M.P.Heyn (1988)
Distributed kinetics of the light-induced charge movements in bacteriorhodopsin, Biophys. J. 53:623-633.
12. D.Braun, N.A.Dencher, A.Fahr, M.Lindau and M.P.Heyn (1988)
Nonlinear voltage dependence of the proton pump current of bacteriorhodopsin, Biophys. J. 53:617-621.
11. M.Lindau and E.Neher (1988)
Patch-clamp techniques for time-resolved capacitance measurements in single cells, Pflügers Arch. 411:137-146.
10. E.Neher, J.M.Fernandez and M.Lindau (1987)
The calcium dependence of vesicle exocytosis, in: Molecular Neurobiology in Neurology and Psychiatry, ed. E.R.Kandel, Raven Press, New York: 103-110.
9. M.Lindau and O.Nüße (1987)
Pertussis toxin does not affect the time course of exocytosis in mast cells stimulated by intracellular application of GTP-γ-S, FEBS Lett. 222:317-321.
8. J.M.Fernandez, M.Lindau and F.Eckstein (1987)
Intracellular stimulation of mast cells with guanine nucleotides mimick antigenic stimulation, FEBS Lett. 216:89-93.
7. M.Lindau and J.M.Fernandez (1986)
A patch-clamp study of histamine-secreting cells, J. Gen. Physiol. 88:349-368.
6. M.Lindau and J.M.Fernandez (1986)
IgE-mediated degranulation of mast cells does not require opening of ion channels, Nature 319:150-153.
5. M.Lindau and H.Rüppel (1985)
On the nature of the fast light-induced charge displacement in vertebrate photoreceptors, Photobiochem. Photobiophys. 9:43-56.
4. M.Lindau (1984)
Lichtinduzierte Ladungsbewegungen des Rhodopsins, Dissertation Technische Universität Berlin.
3. M.Lindau and H.Rüppel (1983)
Evidence for conformational substates of rhodopsin from kinetics of light-induced charge displacement, Photobiochem. Photobiophys. 5:219-228.
2. P.Hochstrate, M.Lindau and H.Rüppel (1982)
On the origin and signal-shaping mechanism of the fast photo-signal in the vertebrate retina, Biophys. J. 38:53-61.
1. M.Lindau, P.Hochstrate and H.Rüppel (1980)
Two component fast photo-signals derived from rod outer segment membranes attached to porous cellulose filters, FEBS Lett. 112:17-20.