Graduate Programs in the Life Sciences

Research Focus

Regulation in Cellular Signal Transduction

Cells respond to a large variety of signals using only a limited set of signaling modules which are organized in complex networks. The activity of these signaling switches is spatially and temporally regulated, and this regulation governs normal development and cellular homeostasis. Consequently, uncontrolled activation is a hallmark of many diseases such as cancer. It is therefore not surprising that the cell has intricate regulatory mechanisms in place to control signal transduction.

Dr. Sondermann's lab is interested in deciphering the basic regulatory principles in signal transduction networks on a molecular level, focusing on growth factor receptor signaling. In particular, they study the role of scaffolding proteins and other regulators signal transduction in this pathway, using a combination of X-ray crystallography, biophysical and cellular approaches. Scaffolds, which serve as docking hubs for the signaling switches, provide specificity and higher-order control in signaling reactions. Understanding the architecture, mode of action and regulation of these processes will elucidate how cells respond to various inputs producing distinct outputs by using a limited set of molecules.

Educational Background

• Ph.D., Max-Planck-Institute of Biochemistry, Martinsried, Germany, 2001
• Diploma in Biology, University of Cologne, Germany, 1997
• Abitur, Kaiserin-Theophanu-Gymnasium, Cologne, Germany, 1992