Graduate Programs in the Life Sciences

Research Focus

My laboratory studies the genetics of epilepsy. We employ Drosophila as a model system for studying epilepsy. Certain classes of Drosophila mutants called bang-sensitives undergo seizures during mechanical stimulation. The bang-sensitive phenotype has several features: the flies have an initial seizure, paralyze, seize again, and then become resistant to further seizures. It is possible to select for genes that suppress or enhance any aspect of the bang-sensitive phenotype. In my lab, we plan to identify genes involved in epileptogenesis through a genome-wide screen for enhancers and suppressors of bang-sensitivity. By identifying genes in epileptogenesis, we hope to identify new drug targets by which epilepsy may be treated.