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Susan A. Henry

Ronald P. Lynch Dean of Agriculture and Life Sciences

Primary Research Areas

  • biochemistry
  • cell biology
  • genetics
  • molecular biology
  • molecular genetics

Graduate Fields

Research Focus

The research in Susan Henry`s laboratory focuses on regulation of membrane lipid metabolism in yeast and its coordination with membrane trafficking and signal transduction. Most recently, the Henry lab has shown that signals arising from lipid metabolism in the endoplasmic reticulum (ER) influence major transcriptional networks in the cell.

Research Grants

  • GENE REGULATION OF PHOSPHOLIPID SYNTHESIS IN YEAST

Selected Publications

PubMed Listings

S. A. Jesch, X. Zhao, M. T. Wells, and S. A. Henry. 2005. Genome Wide Analysis Reveals Inositol, Not Choline, as the Major Effector of Ino2p-Ino4p and Unfolded Protein Response Target Gene Expression in Yeast. J. Biol. Chem., 280: 9106-9118.

L. R. Nunez and S. A. Henry. 2005. Regulation of 1D-myo-inositol-3-phosphate Synthase in Yeast. In: Subcellular Biochemistry: Biology of Inositols and Phosphoinositides, Ed. A. L. Majumder and B. B. Biswas, Kluwer Academic/Plenum Publishers, London, UK, Vol. 39: 135-156.

S. A. Jesch and S. A. Henry. 2005. Yeast Inositol Lipids: Synthesis, Regulation, and Involvement in Membrane Trafficking and Lipid Signaling. In: Cell Biology and Dynamics of Yeast Lipids, G. Daum (Ed.). Research Signpost, Kerala, India, Vol: 37/661: 105-131.

H. A. Boumann, J. Gubbens, M. C. Koorengevel, C. S. Oh, C. E. Martin, A. J. Heck, J. Patton-Vogt, S. A. Henry, B. de Kruijff, and A. I. de Kroon. 2006. Depletion of Phosphatidylcholine in Yeast Induces Shortening and Increased Saturation of the Lipid Acyl Chains: Evidence for Regulation of Intrinsic Membrane Curvature in a Eukaryote. Mol Biol Cell, 17:1006-1017.

M. L. Gaspar, M. A. Aregullin, S. A. Jesch, and S. A. Henry. 2006. Inositol Induces a Profound Alteration in the Pattern and Rate of Synthesis and Turnover of Membrane Lipids in Saccharomyces cerevisiae. J. Biol. Chem., 281: 22773-22785.

S. A. Jesch, P. Liu, X. Zhao, M. T. Wells, and S. A. Henry. 2006. Multiple endoplasmic reticulum-to-nucleus signaling pathways coordinate phospholipid metabolism with gene expression by distinct mechanisms. J. Biol. Chem., 281: 24070-24083.

Nunez, L. 2006. Phospholipid biosynthesis in yeast: The role of the PKC1-MPK1 signal transduction pathway, Ph.D. Thesis, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.

E. L. Krause, M. J. Villa-Garcia, S. A. Henry, and L. P. Walker.  2007.  Determining the effects of inositol supplementation and the opi1 mutation on ethanol tolerance of Saccharomyces cerevisiae.  Industrial Biotech., 3: 260-268.

G. M. Carman and S. A. Henry.  2007.  Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae.  J. Biol. Chem., 282: 37293-37297.

M. L. Gaspar, S. A. Jesch, R. Viswanatha, A. L. Antosh, W. J. Brown, S. D. Kohlwein, and S. A. Henry.  2008.  A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation.  J. Biol. Chem., 283: 25735-25751.

L. R. Nunez, S. A. Jesch, M. L. Gaspar, C. Almaguer, M. Villa-Garcia, M. Ruiz-Noriega, J. Patton-Vogt and S. A. Henry.  2008.  Cell wall integrity MAPK pathway is essential for lipid homeostasis.  J. Biol. Chem., 283: 34204-24217.