Clare Fewtrell
Associate Professor
Primary Research Areas
- cellular & molecular physiology
- membrane & epithelial physiology
Research Focus
- Calcium as a second messenger in non-excitable cells
- protein kinase C
- exocytosis proteins
- ion channels in mast cells
- Stimulus-response coupling in cells in the immune system and the role of Ca2+ in this process
- Characterizing the immunoglobulin E receptor-activated signal transduction pathway in mucosal mast cells, and in particular the role of Ca2+ and protein kinase C
- Measurements of intracellular Ca2+ and membrane potential using fluorescent probes and quantitative image-enhanced fluorescence microscopy
- Identification of the exocytosis protein that acts as the Ca2+ sensor in mast cells
- Indo-1 photometry and constant-potential amperometry are being used to monitor intracellular Ca2+ and serotonin secretion at the single-cell level, with high temporal resolution
- Characterizing the relationship between release of Ca2+ from intracellular stores, ion channel activation, oscillations in cytoplasmic Ca2+ and the individual exocytotic events occurring in a single cell
Educational Background
- D.Phil., Pharmacology, Oxford University
