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Eric Young Denkers

Professor

Research Focus

  • Basis of host immunity to microbial pathogens

  • Cellular and molecular responses to the opportunistic protozoan parasite, Toxoplasma gondii, using the mouse as an experimental model

  • Dissecting early events involved in immunity to this parasite

  • Role of neutrophils during toxoplasmosis
  • Polymorphonuclear leukocytes (PMN) in establishment of immunity to microbial infection
  • Effects of PMN depletion on the immune response in mice
  • Examining neutrophil interactions with other cells of the immune system
  • Spectrum of cytokines released by PMN during infection
  • Host intracellular signaling pathways during Toxoplasma infection
  • How intracellular signaling cascades within the host cell are influenced by the presence of an ongoing infection
  • Determining which signaling pathways are activated, and which may be disabled, by intracellular infection

Educational Background

  • BS, Biology, University of Washington, 1982
  • PhD, Molecular Biology, University of Wisconsin-Madison, 1990

Research Grants

  • IMMUNOBIOLOGY OF PARASITIC DISEASES
  • SIGNAL TRANSDUCTION DURING TOXOPLASMA INFECTION
  • ROLE OF CCL2/MCP-1 IN MUCOSAL IMMUNITY TO TOXOPLASMA
  • SIGNAL TRANSDUCTION DURING TOXOPLASMA INFECTION
  • ROLE OF NEUTROPHILS DURING TOXOPLASMOSIS